Akademik Dersler - İçerik

Will be able to Evaluate Granulated Type Drug Delivery Systems.
• Describes the relationship between powder-granule-tablet. • Defines the granule. • Explains the types of granules. • Describes the physical properties of the granule. • Explains the purpose of preparing granules. • Evaluates the superiority of using powder in tablet preparation. • Evaluates the inconvenience of using powder in tablet preparation. • Evaluates the superiority of using granules in tablet preparation. • Evaluates the inconvenience of using granules in tablet preparation. • Lists granule preparation methods. • Describes the dry granulation method. • Draws work flow chart for dry granulation method. • Describes the cases where dry granulation method is preferred. • Describes the equipment and materials required for the dry granulation method. • Describes the devices used for mixing powders for small scale production. • Describes the devices used in the mixing of powders for industrial production. Lists dry granulation methods. • Describes the most used dry granulation method in the industry. • Explains the pre-compression method. • Describes the method of compression between rollers. • Explain the concept of briquette tablet. • Defines wet granulation method. • Draws work flow chart for wet granulation method. • Describes the situations in which the wet granulation method is preferred. • Describes the equipment and materials required for wet granulation method. Lists wet granulation methods. • Explains the most used wet granulation method in the industry. • Defines effervescent granule. • Describes the auxiliary substances that give effervescence. • Explains the reason for effervescence. • Describes the necessary equipment and materials for the preparation of effervescent granules. • Draws a work flow chart for the preparation of effervescent granules. • Makes the necessary calculations for the preparation of effervescent granules. • Describes the difference between anhydrous citric acid and aqueous citric acid. • Lists granule control. • Explains the importance of uniform particle size in granules. • Describes the difference between particle size and distribution in the granule. • Discusses the effect of change in particle size in the granule on the total surface area. • Discusses the effect of change of particle size on the rheology to the rheology. • Describes the methods used to measure particle size and distribution in the granule. • Describes the device and material required for the measurement of particle size and distribution in the granule. • Explains the difference between sieving and microscope method. • Describes the method used for microscope study in granules. • Describes the equipment and materials required for microscope operation in granules. • Describes the data required to present the result of microscope study in the granule. • Describes the result evaluation criteria of microscope study in granules. • Describes the method used for sieve analysis work in granules. • Describes the equipment and materials required for sieve analysis work in granules. • Describes the data required to present the result of sieve analysis work in the granule. • Describes the result evaluation criteria of sieve analysis study in granules. • Describes the methods used to determine the rheological properties of the granule. • Describes the fluency study by measuring the pile angle in the granule. • Describes the device and material required for fluency study with the bulk angle measurement in the granule. • Describes the data required for presentation in the fluency study with the stack angle measurement in the granule. • Describes the result evaluation criterion of fluency study with bulk angle measurement in granule. • Describes the running time determination of granule work. • Describes the equipment and materials required for the determination of run time in the granule. • Describes the data required to present the yield time determination work in the granule. • Describes the result evaluation criterion of the flow time determination study in granules. • Describes the methods used to determine the compressibility of the granule. • Describes the application of cluster density study in granules. • Describes the equipment and materials required for cluster density study in granules. • Describes the data required to present the result of the batch density study in the granule. • Describes the result evaluation criteria of cluster density study in granules. • Explains the execution of stroke intensity study in the granule. • Describes the equipment and materials required for the stroke density operation in the granule. • Describes the data required to present the result of the stroke intensity study in the granule. • Describes the result evaluation criteria of stroke intensity study in granule. • Evaluates the relationship between aggregate density and stroke density in the granule. • Describes the method used to determine the amount of moisture in the granule. • Describes the equipment and materials needed to determine the moisture content in the granule. • Describes the data required to present the result of moisture content study in the granule. • Describes the result evaluation criteria of moisture content study in granules. • Describes the methods used to determine the amount of carbon dioxide in the granule. • Compares the methods used in determining the amount of carbon dioxide in the granule. • Describes the situations where the amount of carbon dioxide in the granule should be determined. • Describes the equipment and materials needed to determine the amount of carbon dioxide in the granule. • Describes the data that should be presented in determining the amount of carbon dioxide in the granule. • Describes the results evaluation criteria for determining the amount of carbon dioxide in the granule. • Describes the most effective method used to determine the amount of carbon dioxide in the granule.
Will be able to Evaluate Tablets.
• Defines the tablet. Lists the general feature of the tablet. • Lists the features that the ideal tablet should have. • Compares the tablet numerically with pharmaceutical forms on the market. • Numerically compares the tablet to pharmaceutical forms used orally on the market. • Lists tablet types according to their shape. • Categorizes the tablet according to its intended use. • Compares the tablet according to its intended use. • Gives examples of externally used tablets. • Explain the tablet shapes used externally. • Compares the effectiveness of dry, solution or mucilage binder. • It gives an example of the binder used in the tablet formulation. • Describes the intended use of the lubricant used in the tablet formulation. • Explains the friction reduction mechanism of the lubricant. • Describes the amount of lubricant used in the tablet formulation. • Classifies the lubricants used in the tablet formulation. • Describes the intended use of the lubricant used in the tablet formulation. • It gives an example of the lubricant used in the tablet formulation. • Describes the intended use of the glidan substance used in tablet formulation. • Gives an example to the glidan substance used in tablet formulation. • Describes the use of anti-adheren substance used in tablet formulation. • Exemplifies the anti-adherent substance used in the tablet formulation. • Compares the effectiveness of the lubricant, glidan and anti-adheren substance. • Determines the amount of lubricant to be added to the tablet formulation. • Describes the effectiveness factor of the lubricant to be added to the tablet formulation. • Explains the purpose of the dye used in the tablet formulation. • Explains the purpose of using buffering agent used in tablet formulation. • Explains the purpose of using the sweetening agent used in tablet formulation. • Describes the use of wetting agent used in tablet formulation. • Explains the purpose of using the matrix forming agent used in tablet formulation. • Classifies the excipient used in the tablet formulation according to their structure. • Describes the intended use of cellulose and its derivatives used in tablet formulation. • It gives an example of cellulose and its derivative used in tablet formulation. • Explains the purpose of starch used in tablet formulation. • It gives an example of starch derivative used in tablet formulation. • Describes the use of sugar and polyacol used in tablet formulation. • Gives examples of sugar and polyacol used in tablet formulation. • Explains the purpose of using synthetic organic material used in tablet formulation. • It gives an example of synthetic organic material used in tablet formulation. • Explains the purpose of the mineral substance used in tablet formulation. • It gives an example of the mineral substance used in the tablet formulation. • Describes the use of antistatic agent used in tablet formulation. • It gives an example of antistatic agent used in tablet formulation. • Classifies tablet preparation methods. • Explains the points to be considered in the selection of tablet preparation method. • Describes the method of preparing tablets with direct pressure. Lists the superiority of the method of preparing tablets with direct pressure. • Explains the factors that are effective in the method of preparing tablets with direct pressure. • Describes the necessary equipment and materials for the method of preparing tablets with direct pressure. • Draws a work flow chart for the method of preparing tablets with direct pressure. • Explains tablet preparation methods after granulation. • Describes the method of preparing tablets after dry granulation. • Draws work flow chart for tablet preparation method after dry granulation. • Describes the method of preparing tablets after wet granulation. • Draws work flow chart for tablet preparation method after wet granulation. • Compares wet granulation method with direct pressure and tablet preparation method. • Describes the intended use of the tablet machine. • Explains the basic parts of the tablet machine on the figure. • Describes the purpose of the funnel, magazine, stamp, punch and adjustment screw. • Describes situations where tablet hardness, weight and shape should be changed. • Describes the actions to be taken to change the pressure applied on the tablet. • Describes the procedures for changing the tablet weight. • Describes the operations to be done to change the tablet diameter. • Describes the actions to be taken to change the shape of the tablet. • Explains the working principle of single punch tablet machine. • Describes the compression cycle of the single punch tablet machine on the figure. • Describes the working principle of the rotari tablet machine. • Classifies the rotari tablet machine according to its intended use. • Rotari pressing a conventional tablet explains the compression cycle of the machine. • Rotari pressing a multilayer tablet explains the compression cycle of the machine. • Rotating the Mantel tablet explains the compression cycle of the machine. • Explains the difference between conventional, multi-layer and mantel tablet. • Compares the superiority of a single punch tablet machine and a rotari tablet machine. • Compares the drawback of the single punch tablet machine and the rotari tablet machine. • Explains the importance of punch set used in tablet press. • Describes the type of material used for the punch set used in tablet printing. • Explains the mechanical problems encountered in tablet pressing. • Explains the reason of mechanical problems encountered in tablet pressing. • Describes the solution of mechanical problems encountered in tablet pressing. • Explains the chemical problems encountered in tablet press. • Describes the solution of chemical problems encountered in tablet press. Lists the factors affecting tablet press. • Explains the effect of active substance feature on tablet production. • Describes the effect of used excipient on tablet press. • Explain the effect of granule size and distribution on tablet press. • Explains the importance of moisture in tablet press. • Describes the effect of the tablet machine on the pressing speed in tablet pressing. • Describes the effect of pressure applied to powder or granule in tablet press. • Explains the effect of preparation method on tablet press. • Explains the importance of tablet control. • Evaluates tablet control before production, during production and after production. • Explains the importance of initial substance control in tablet production. Lists the stages of starting substance control in tablet production. • Explain the importance of intermediate product control in tablet production. • Lists the stages of intermediate product control in tablet production. • Explains the importance of finished product control in tablet production. • List the stages of the tablet in the finished product control. • Lists the tablet's finished product control. • Describes the official sources used in the assessment of the finished product control of the tablet. • Lists organoleptic control on the tablet. • Explains the importance of organoleptic control on the tablet. • Explains the organoleptic control on the tablet. • Describes the evaluation criteria of organoleptic control on the tablet. • Explain the importance of diameter and thickness control on the tablet. • Explains the diameter and thickness control on the tablet. • Describes the device and material required for diameter and thickness control on the tablet. • Describes the evaluation criteria of diameter and thickness control on the tablet. • Explain the importance of hardness control on the tablet. • Explains the hardness control on the tablet. • Describes the device and material required for hardness control on the tablet. • Describes the evaluation criteria of hardness control on the tablet. • Explain the importance of crumbling and abrasion test on the tablet. • Explains the crumbling-wear test on the tablet. • Describes the equipment and materials required for crumbling and wear test on the tablet. • Describes the evaluation criteria of crumbling and abrasion test on the tablet. • Explains the importance of mass uniformity test on tablet. • Explains how to perform mass uniformity test on tablet. • Describes the device and material required for testing the uniformity of mass on the tablet. • Describes the evaluation criterion of mass uniformity test on tablet. • Explain the importance of content uniformity test on tablet. • Explains the content uniformity test on the tablet. • Describes the device and material required for testing content uniformity on the tablet. • Makes the necessary calculations for the content uniformity test on the tablet. • Describes the evaluation criteria of the content uniformity test on the tablet. • Explains the importance of tablet dissolution rate test. • Describes the dissolution rate test on the tablet. • Describes the methods used for tablet dissolution rate test. • Describes the equipment and materials required for the dissolution rate test on the tablet. • Makes the necessary calculations for the dissolution rate test on the tablet. • Describes the evaluation criterion of tablet dissolution rate test. • Kinetically evaluates the dissolution rate test on the tablet. • Explain the importance of disintegration test on tablet. • Explains the disintegration test on the tablet. • Describes the device and material required for the disintegration test on the tablet. • Describes the evaluation criteria of disintegration test on tablet. • Describes the situations where the disintegration test cannot be applied on the tablet. • Explain the factors affecting the disintegration in the tablet. • Explain the purpose of tablet coating. • Explains tablet coating types. • Explains the properties of the core tablet in tablet coating. • Explains sugar coating method. • Explains the advantages and disadvantages of sugar coating method. • Explains the materials used in sugar coating. • Explains sugar coating stages and layers. • Explain the error and the reason that may occur in sugar coating. • Explains the solution of the error that may occur in sugar coating. • explains the film coating method. • Explains the advantages and disadvantages of the film coating method. • Compares sugar and film coating. • Describes the properties of the film-making material. • Describes the materials used in film coating. • Explains the error and the reason that may occur in film coating. • Describes the solution of the error that may occur in film coating. • Explains the purpose of enteric coating. • Describes the materials used in enteric coating. • Describes the pressure coating method. • Explains the advantages and disadvantages of pressure coating method. • Describes the controls on the coated tablet. • Describes the tools used for the coating process. • Describes coating method and boiler type in the boiler. • Explains the coating in fluidized bed system. • Describes the devices used in pressure coating.
Will be able to Evaluate Modified Drug Delivery Systems.
• Classifies the systems showing modified emissions. • Explains the concept of modified drug release. • Illustrates the modified drug delivery system. • Explains the advantages of the modified drug delivery system. • Explains the disadvantages of the modified drug delivery system. • Compares the modified drug delivery system with the conventional system. • Describes the properties of the active substance candidate for the modified drug delivery system. • Classifies the polymer to be used in the modified drug delivery system. • Describes the properties of the polymer to be used in the modified drug delivery system. • It gives an example of the polymer to be used in the modified drug delivery system. • Describes the active substance release mechanism in the modified drug delivery system. • Describes the release kinetics in the modified drug delivery system. • Describes the ideal release kinetics in the modified drug delivery system. • Draws release profiles in the modified drug delivery system. • Explains the pharmacokinetic basis of the modified drug delivery system. • Classifies diffusion controlled system. • Explains the features of diffusion controlled system. • Explains the difference between membrane and matrix system. • Describes the active substance release in the membrane and matrix system. • Membrane and matrix give an example to the system. • Classifies the chemical controlled system. • Classifies the system activated by the solvent. • Illustrates the application route of the modified drug delivery system. • Classifies the modified drug delivery system according to its structure. • Explains the particulate drug delivery system. • Explains the structural feature of the microcapsule. • Explains the purpose of microcapsule preparation. • Explains the properties of the core and the wall substance in the microcapsule. • Explains microcapsule preparation method. • Explains the points to be considered in the selection of microcapsule preparation method. • Describes the characterization work done in the microcapsule. • Describes the parameters affecting the active substance release in the microcapsule. • Explains the structural feature of the microsphere. • Explains the purpose of preparing microsphere. • Explains the superiority of using natural polymer in microsphere preparation. • Explains the superiority of using synthetic polymer in microsphere preparation. • explains microsphere preparation methods. • Describes the characterization study in the microsphere. • Describes the parameters affecting the active substance release in the microsphere. • Explains the application area of microcapsule and microsphere. • Compares microcapsule and microsphere on shape. • Explains the concept of nanoparticle. • Explains the structural feature of the nanoparticle. • Explains the difference between nanoparticle and microparticle. • Explains nanoparticle preparation methods. • Describes the characterization study in nanoparticle. • Explains the application areas of nanoparticle. • Describes the structural feature of the solid lipid nanoparticle. • Explains the advantages and disadvantages of the solid lipid nanoparticle. • Describes the methods of preparing solid lipid nanoparticles. • Describes the characterization study in solid lipid nanoparticle. • Explains the application area of solid lipid nanoparticle. • Explains the porous polymeric system. • Explains the structural properties of the micro sponge. • Explains the superiority and disadvantage of the micro-sponge. • Explains microsponge preparation methods. • Describes the characterization work in the microsponge. • Explains the application area of the microsphere. • Describes the vesicular drug delivery system. • Explains the structural feature of the liposome. • Explains the superiority and disadvantage of liposome. • Categorizes the liposome according to its layer. • Shows the liposome on the figure. • Explains the liposome preparation methods. • Explains the loading of active substance to liposome. • Explains the ways the liposome is given to the body. • Describes the characterization study in the liposome. • Explains the application area of liposome. • Explains the liposome with its feature. • Explains the structural feature of the niosome. • Compares the properties of niosomes and liposomes. • Explains niosome preparation methods. • Describes the application area of the niosome. • Describes the emulsion drug delivery system. • Defines microemulsion and nanoemulsion system. • Explains the superiority and disadvantage of microemulsion and nanoemulsion system. • Explains the application area of microemulsion and nanoemulsion system. • Describes the molecular drug delivery system. • Explains the structural feature of the inclusion complex. • Explains the advantages and disadvantages of the inclusion complex. • It shows the inclusion complex on the figure. • Explains the methods of preparation of inclusion complex. • Explains loading the active substance to the inclusion complex. • Describes the characterization study in the inclusion complex. • Explains the application area of the inclusion complex. • Explains the structural properties of the molecular printed polymeric system. • Explains the advantages and disadvantages of the molecular printed polymeric system. • Explain molecular suppression and synthetic specific molecular recognition. • Describes the preparation methods of the molecular printed polymeric system. • Explains the loading of active substance in the molecular printed polymeric system. • Describes the characterization work in the molecular printed polymeric system. • Explains the application area of the molecular printed polymeric system. • Classifies the controlled drug delivery system according to the route of administration. • Explains the feature of oral modified release system. • List the parameters that are important in the effectiveness of the oral modified delivery system. • Explains the superiority of the oral modified delivery system over other oral conventional drug forms. • Classifies the oral modified release system. • Describes the feature of the membrane controlled oral system. • Explains the feature of the matrix controlled oral system. • Explains the feature of the oral system that is worn in the body. • Describes the feature of the swelling controlled oral system. • Explains the feature of osmotic controlled oral system. • Explains the feature of modified oral system depending on time. • Explains the release of active substance from the oral modified delivery system. • It gives an example of oral modified release system. • Describes the application area of the oral modified delivery system. • Describes the feature of the oral modified delivery system retained in the stomach. • Lists the types of oral modified delivery system kept in the stomach. • Describes the feature of an oral modified delivery system that delays gastric emptying. Lists the variants of the oral modified delivery system that delays gastric emptying. Lists the types of oral modified delivery system floating in the stomach. • Describes the feature of the modified release system adhering to the mucosa. • Describes the feature of the bioadhesive modified release system. • Explains the advantages and disadvantages of the bioadhesive modified emission system. • Bioadhesive shows the modified release system on the figure. • Explains the bioadhesion theory. • Explains the stages of bioadhesion. • Explains the factors affecting bioadhesion. • Describes the characterization study in the bioadhesive modified release system. • Describes the application area of the bioadhesive modified emission system. • Bioadhesive modified exemplary system. • Explains the feature of the ocular modified delivery system. • Classifies the ocular modified delivery system. • Ocular viscous polymer gives an example of solution and gel. • It gives an example to the ocular colloidal system. • Explains the superiority and disadvantage of ocular microemulsion. • Explains the feature of the ocular insert. • Explains the purpose of the ocular insert. • Gives an example to the ocular insert. • Explains the feature of the ocular implant. • Explains the purpose of the ocular implant. • Gives an example to the ocular implant. • Describes the feature of nasal modified release system. Explains the superiority and disadvantage of nasal modified release system. • Describes the methods used to increase nasal absorption. • Describes the application area of nasal modified release system. • Nasal modified release gives an example to the system. • Describes the feature of the pulmonary modified release system. • Explains the advantages and disadvantages of the pulmonary modified release system. • Explains approaches to drug administration to lungs. • Describes the application area of the pulmonary modified release system. • Pulmonary modified release gives an example to the system. • Describes the feature of the transdermal modified release system. • Explains the advantages and disadvantages of the transdermal modified release system. • Classifies the transdermal modified release system. • Describes the application area of the transdermal modified release system. • Transdermal modified release gives an example of the system. • Describes the characterization study in transdermal modified release system. • Describes the feature of the vaginal modified release system. • Explains the advantages and disadvantages of intravaginal drug administration. • Classifies the vaginal modified release system. • Describes the application area of the vaginal modified delivery system. • Vaginal modified release gives an example to the system. • Explains the feature of the system placed in the uterus. • Gives an example to the system placed in the uterus. • Describes the feature of the rectal modified release system. • Explains the advantages and disadvantages of rectal medication. • Classifies rectal modified release system. • Describes the application area of the rectal modified release system. • Rectal modified release gives an example to the system. • Describes the feature of the system carrying the drug to the column. • Describes the factors affecting the absorption of the active substance from the colon. • Describes the feature of the oral system that carries drugs to the colon. • Classifies the oral system that carries drugs to the colon. • Describes the application area of the oral system carrying drugs to the column. • It gives an example to the oral system that carries drugs to the colon. • Describes the modified release system based on pH and time when transporting drugs to the column. • Describes the pressure-dependent modified release system for drug delivery to the column. • Describes the modified release system due to microbial enzyme in carrying drugs to the column. • Describes the purpose of targeting modified emission system. • Explains the reason for pharmaceutical and biopharmaceutical targeting. • Explains the reason for targeting in terms of pharmacokinetics and pharmacodynamics. • Explains the reason for clinical targeting. • Explains the reason for commercial targeting. Lists the biological factors effective in targeting. • Lists the factors related to the active substance effective in targeting. • Lists the factors of the carrier system effective in targeting. • Explains targeting mechanism. • Explains the purpose of passive targeting. • Explains the feature of passive targeting. • Gives an example of passive targeting. • Explains the importance of particle size in passive targeting. • Explains the importance of the surface properties of the carrier system in passive targeting. • Explains the importance of the reticuloendoterial system (RES) and EPR effect in passive targeting. • Explains the purpose of active targeting. • Explains the feature of active targeting. • It gives an example of active targeting. • Explains the feature of magnetic targeting. • Explains the purpose of magnetic targeting. • Gives an example of magnetic targeting. • Explains the feature of ultrasonic targeting. • Explains the purpose of ultrasonic targeting. • Gives an example of ultrasonic targeting. • Describes the feature of ligant-receptor mediated targeting. • Explains the purpose of ligant-receptor mediated targeting. • It gives an example of ligant-receptor mediated targeting. • Describes the purpose of compound targeting. • Describes the feature of compound targeting. • Illustrates composite targeting. • Describes bioavailability studies in the modified drug delivery system. • Describes the stages of bioavailability and bioequivalence in the modified drug delivery system. • Explains the relationship between bioavailability and active substance in the modified drug delivery system. Explains the relationship between bioavailability and dosage form in the modified drug delivery system. • Explains possible bioavailability problems in the oral modified delivery system. Explains in vitro dissolution rate test in modified drug delivery system. • Compares in vitro dissolution rate profiles in the modified drug delivery system. • Interprets the dissolution rate profiles in the modified drug delivery system.
Will be able to Evaluate Agrochemicals.
• Defines pesticide. • Explains the purpose of pesticide use. • Classifies the active substance used in pesticides according to their intended use. • Gives an example to the active substance used in pesticides. • Explains the points to be considered in the preparation of pesticides. • Describes the color of the pesticide label and the properties of the colors. • Explains the points to be considered in the use of pesticides. • Explains the points to be considered in pesticide storage. • Explains poisoning symptoms that can be seen in pesticide use. • Classifies pesticides according to their toxicological characteristics. • Describes the warning signs used in pesticide packaging. • Gives an example to herbicides. • Pesticide gives examples. • Gives examples to the plant organizer.
Will be able to Evaluate Veterinary Medicines.
• Defines veterinary medicine. • It explains the purpose of the veterinary medicine. • Classifies the active substance used in veterinary medicine according to its purpose of use. • Gives an example to the active substance used in veterinary medicine. • Describes the animal species to which the veterinary medicine is applied. • Describes the application methods of veterinary medicine. • Explains the points to be considered in the use of veterinary medicines. • Explains the points to be considered in veterinary drug storage. • Lists the veterinary drug delivery system. • Classifies the veterinary drug delivery system used orally. • Describes the feature of the oral veterinary drug delivery system showing modified drug release. • Explains the superiority of the use of injection dosage form as veterinary medicine. • Describes the dosage form applied to the body cavity as a veterinary medicine. • Describes topically applied dosage form as veterinary medicine. • Describes the liquid dosage form used as a veterinary medicine. • Identifies the biotechnological veterinary medicinal product and its properties. • Defines the veterinary medicated premix and its properties. • Defines the medicated feed and its properties. • Describes the feature of the packaging used for veterinary medicine. • Describes the prescription used for veterinary medicine. • Describes prescription and non-prescription veterinary medicines. • Explains the importance of veterinary drug residues in foods. • Evaluates veterinary drug residues in foods for negative effects. • Explains the reason for off-label use in veterinary medicine. • Describes the signs and shapes used in veterinary medicine prescription. • Describes the feature of the solvent used for veterinary medicine. • Explains the information leaflet required for veterinary medicine. • Explains the treatment class for veterinary medicine.
Will be able to Evaluate GMP / GLP Concepts.
• Explains the concept of GLP and GMP. • Lists legislation related to GLP and GMP. • Describes important terminology related to GMP and GLP. • Explains the importance of GLP and GMP in pharmaceutical technology. • Explains the relationship between drug production stage and quality. • Explains the concept of quality in medicine. • Describes the steps required to ensure the quality of the drug. • Describes the ICH documents prepared for the quality standard and method. • Defines the validation. • Explains the importance of validation in medicine. Lists the benefits of validation in medication. • Describes the phase and working levels of the design process, validation. • Explain the dosage form priority of the FDA in process validation. • Lists the types of validation. • Explains analytical validation. • Lists the validation parameters. • Explain ICH documents related to validation. • Describes the actions to be taken to prove the validity of the product. • Explains the necessity of documentation in GMP. • Explains the concept of quality in industrial production process. • Explains the feature that the production place should have. • Explains the health conditions to be complied with at the production site. • Explains the rules that the personnel must follow at the production site. • Describes the feature that the devices in the production place should have. • Explains the importance of raw material control at the production site. • Explains issues to be considered during production. • Lists the issues to be followed for quality control in production. • Explains the structure of the quality assurance system. • Defines quality management. • Defines quality assurance. • Defines quality control. • Explains the detection of errors and types of errors. • Explains the importance of the auto control system during production.
Will be able to EvaluatePharmaceutical Biotechnology.
• Interprets the separation and relationship of pharmaceuticals, biologicals and biopharmaceuticals. • Defines biotechnology • Explain the uses of biotechnology in various fields (food, medicine, plant, environment and genetics). • Explains the relationship between biopharmaceuticals and pharmaceutical biotechnology • Defines Pharmaceutical Biotechnology • Explains Pharmaceutical Biotechnology research topics • Explains the historical development of Pharmaceutical Biotechnology • Recognizes the biological fermentation products that have been used as medicine and have reached to date. • Explains the relationship of Pharmaceutical Biotechnology with other disciplines. • Describes the historical development of biopharmaceuticals
Will be able to Evaluate Production of Antibiotics and Vitamins by Fermentation.
• Identifies genes in penicillin biosynthesis • Describes [penicillin G] biosynthesis of benzylpenicillins • Explains penicillin biosynthesis and purification methods • Explain streptomycin biosynthesis • Explain Tetracycline biosynthesis • Explains Riboflavin Biotechnological Synthesis • Describes the Biological Processes Used for Nicotinic Acid (Vit B3) Production • Explains the Biological Processes Used for the Production of Pantothenic Acid (Vit B5) • Describes the Biological Processes Used for the Production of Cobalamin (Vitamin B12) • Explain the Biological Processes Used for Coenzyme Q10 (Vitamin Q10) Production • Describes the Biological Processes Used for the Production of L-Ascorbic Acid (Vitamin C)
Will be able to Evaluate the Concepts of Recombinant DNA Technology and Biotechnology.
• Describes the historical development of recombinant DNA technology Lists the uses of recombinant DNA technology • Explains the building blocks of nucleic acids • Explains the functions of nucleic acids • Explains the differences between nucleic acids • Defines the vectors used in recombinant DNA technology • Recognizes plasmids • Explains plasmid DNA production • Identifies bacteriophages • Defines cosmids Identifies bacterial artificial chromosomes (BAC) • Identifies yeast artificial chromosomes (YAC) Identifies mammalian artificial chromosomes (MAC) Identifies human artificial chromosomes (HAC) Defines expression vectors • Defines the construction endonucleases • Explains the functions of construction endonuclease • Classifies the construction endonucleases • Describes the naming of the construction endonucleases • Explain isochisomers • Describes restriction endonucleases that make different recognition on DNA • Explains the areas of use of construction endonucleases • Classifies host cells Classifies DNA sequence analysis • Describes the enzymatic method (Sanger Method) in DNA sequence analysis • Explains Chemical method (Maxam-Gilbert Method) in DNA sequence analysis • Describes nucleic acid hybridization • Explains DNA hybridization with Southern transfer • Explains RNA hybridization with Nouthern transfer. Describes Polymerase Chain Reaction (PCR or PCR) • Classifies the devices used in Polymerase Chain Reaction • Counts the materials and materials required in the Polymerase Chain Reaction • Explains gene cloning steps • Explains locating, extracting and reproducing the gene. Counts the methods for determining the location of the gene • Describes in vitro methods for locating the gene. • Describes hybridization methods in determining the location of the gene. • Explains Dot Blot Method • Describes the methods used to prevent recirculation after gene removal. • Identifies DNA cloning • Describes the cloning of large DNA fragments to special cloning vectors. • Describes the cloning of eukaryotic DNA to bacterial plasmids. • Describes the cloning of eukaryotic DNA to the phage genome. • Describes the cloning of complementary DNA (cDNA) s. • Counts gene transfer methods • Explain transformation • Explains Agrobacterium-linked gene transfer • Defines direct gene transfer methods • Explains gene transfer by chemical methods. • Explains gene transfer with electroporation method • Explains particulate gene transfer with gene weapon • Explains gene transfer with liposome • Explains gene transfer by microinjection • Explains gene transfer by macroinjection • Explains Laser Source gene transfer • Defines transformation by ultrasonication Compares organizational, cellular and molecular conjugation • Explains gene transfer with transduction • Counts Protoplast fusion types • Defines gene transfer by spontaneous fusion Counts gene transfer with induced fusion Sodium nitrate (NaNO3) defines effective gene transfer • Defines effective gene transfer in Calcium ion (Ca2 +) at high pH • Defines gene transfer by using propylene glycol (PEG) • Explains fusion gene transfer by electrical stimulation. • Explain the colony selection of vectors carrying recombinant gene. • Describes colony hybridization for vectors carrying the recombinant gene. • Explains immunological methods for determining vectors carrying recombinant gene. • Describes the control of the recombinant gene product obtained.
Will be able to Evaluate Recombinant Protein Formulation, Pharmacopoeia Analysis and Quality Control.
• Classifies therapeutic proteins according to their biological functions • Recognizes the primary structure of the target protein • Determines the peptide bonds of the target protein • Recognizes the amino acid sequence of the target protein • Discusses polypeptide synthesis of target protein • Recognizes the secondary structure of the target protein • Recognizes the tertiary structure of the target protein • Recognizes the quaternary structure of the target protein • Discusses the stability and folding of the target protein • Discusses the estimated structure of the target protein • Discusses post-translational modifications of the target protein • Discusses protein glycation • Explain protein carboxylation and hydroxylation. • Discusses the importance of protein sulfate and amidation. • Identifies m-RNA by target protein analysis and identifies cDNA preparation with reverse transcriptase • Explains the preparation of double stranded DNA from cDNA and replication of DNA. • Discusses the transfer of the replicated DNA to the vector • Interprets the selection of the host cell to which the vector will be transferred. • Discusses the protein expression provided by the gene transferred to the host cell • Discusses upstream operations • Discusses the creation of cell banks • Explains the preparation of the master cell bank MCB. • Describes the preparation of the working cell bank WCB. • Defines end of production cells (EOPC) assessment • Discusses the definition of cell line • Discusses the stability of the cell line •Discusses stability in MCB / WCB and EOPC • Discusses the viability of the cell line • Discusses the growth characteristics of the cell line • Discusses the determination of purity in cell line • Describes the investigation of the presence of non-endogenous viruses and adventitious viruses. • Lists the procedures to investigate the presence of retrovirus and endogenous viruses. • Compare characterization in mammalian cell lines • Compares characterization in microbial cell line •Lists the scale-up processes for commercial product development •Classifies fermentation processes on a large scale • Compares fermenters and bioreactors • Defines the specific properties of bioreactors. • Classifies fermenters • Defines solid state fermentation •Compares anaerobic fermentation and aerobic fermentation •Compares mixed tank type fermenters (or Mixed Bioreactors) and air lift type fermenters •Compares immobilized cell bioreactors •Discusses microbial cell fermentation • Discuss the mammalian cell culture system •Compares fermenter variants •Discusses downstream operations • Discusses the first product recovery process • Explain cell disruption • Describes the removal of nucleic acids •Lists the procedures for determining the initial product concentration • Defines the ultrafiltration of the therapeutic protein • Describes the diafiltration of the therapeutic protein • Describes the chromatographic purification of the therapeutic protein • Defines the size exclusion chromatography (gel filtration) of therapeutic protein •Explains ion exchange chromatography method of therapeutic protein • Describes the hydrophobic interaction chromatography method of therapeutic protein. • Describes the affinity chromatography method of therapeutic protein. •Describes the method of purification of therapeutic protein immunoaffinity • Describes protein A chromatography method of therapeutic protein. • Describes the method of lectin affinity chromatography of therapeutic protein. • Describes the method of dye affinity chromatography of therapeutic protein. • Describes the method of metal chelate affinity chromatography of therapeutic protein • Describes the method of therapeutic protein chromatography on hydroxyapatite. • Describes the purity and quantity of therapeutic protein by high performance liquid chromatography (HPLC). • Describes the purification of recombinant therapeutic proteins • Discusses pre-formulation data and adjuvant selection for formula creation • Discusses pharmaceutical drug forms comparatively • Discusses the appropriateness of the ways of application of pharmaceutical drug forms depending on the protein properties. • Classifies the excipients to be put into the formulation according to their purposes. • Lists the stabilizers to be put in the formulation •Discusses formulation development for controlled release and targeting • Describes the necessary procedures to adjust the tonicity • Defines excipient selection • Defines substances that will prevent irreversible aggregation • Counts viscosity increasing agents • Discusses the determination of the size, quaternary structure, aggregation tendency and conformational stability of the protein to be formulated. •Counts the effects that can change the biological activity of proteins •Describes non-covalent changes in protein to be formulated •Defines partial / complete protein denaturation in the protein to be formulated • Identifies covalent changes in protein to be formulated • Defines hydrolysis and oxidation in the protein to be formulated • Describes deamidation and disulfid changes in the protein to be formulated • Defines imine formation and isomerization in protein to be formulated • Defines racification and photodeposition in the protein to be formulated • Defines the proteolytic degradation and the change of sugar side chains in the protein to be formulated. • Explains end product filling methods • Discusses freeze drying method and necessity • Discuss appropriate labeling and packaging methods • Defines protein-based contaminants •Lists the processes of removing the modified forms of the protein associated with the product flow. • Describes the determination of the potential of the product. •List the methods of determining the protein concentration in the finished product • Explain the methods of detection of protein-based product impurities. •List the immunological approaches for the detection of contaminants • Interprets amino acid analysis and application of peptide mapping method to the finished product. • Understands the importance of N-terminal sequencing in the finished product. • Explains the importance of secondary and tertiary structure analysis in the finished product. •List the methods of determining the presence of endotoxin and other pyrogenic contaminants • Describes the presence of microbial and viral contaminants. Lists the validation studies • Discusses the finished product stability studies and methods used. • ICH-Q5A discusses viral safety assessment document of biotechnology products originating from cell lines of human or animal origin. • ICH-Q5B Quality of Biotechnological products: discusses the analysis document of the expression structures in cells used for the production of protein products derived from r-DNA. • ICH-Q5C Quality of Biotechnological products: Discusses the stability test document of Biotechnological / Biological products. • Discusses the document on the Derivation and Characterization of Cellular Substrates •Used for the Production of ICH-Q5D Biotechnological / Biological Products. • Discusses the comparability document of ICH-Q5E Biotechnological / Biological products due to changes in the production process. • Recognizes relevant current guidelines published by EMA, FDA, WHO (WHO), ICH and •ISO that address quality, non-clinical and clinical issues in the development of biosimilar medicinal products. • Ministry of Health Turkey Pharmaceuticals and Medical Devices Agency (TİTCK) 's current guidelines recognize the related biological products
Will be able to Evaluate Cytokines-Interferon Family and Formulations.
• Identifies cytokine receptors • Identifies biopharmaceutical cytokines • Describes the Pharmaceutical Formulation and usage of Interferon-β • Describes the Pharmaceutical Formulation and usage of Interferon-α • Describes the Pharmaceutical Formulation and usage of Interferon-γ • Explains the Biotechnological production of Interleukin-2 and its usage areas in treatment. • Explains the Biotechnological production of Interleukin-1 and its usage areas in treatment. • Explains Biotechnological production of tumor necrosis factor and its usage areas in treatment.
Will be able to Evaluate Growth Factors and Formulations.
• Recognizes the growth factors and classifies them • Classifies hematopoietic growth factors • Explains the Biotechnological production of hematopoietic growth factors. • Identifies interleukins as hemopoietic growth factors and discuss production techniques • Defines the granulocyte colony stimulating factor and discusses the production techniques • Identifies macrophage colony stimulating factor and discusses production techniques • Defines granulocyte macrophage colony stimulating factor and discusses production techniques • Explains the production of Biotechnological Erythropote and explains its usage in treatment. • Explains the production of Biotechnological Thrombopoietin and explains its usage in treatment. • Explains the production of biotechnological insulin-like growth factor and explains the areas of use in treatment. • Explains the production of Biotechnological Epidermal growth factor and explains its usage areas in treatment. • Explains the production of biotechnological platelet-derived growth factor and explains its usage in treatment. • Fibroblast growth factors • Explains the production of Biotechnological Fibroblast growth factor and explains its usage in treatment. • Explains the production of the Biotechnological Neurotrophic factor and explains its usage areas in treatment.
Will be able to Evaluate Hormones and Formulations.
• Lists the production techniques of insulin • Discusses insulin drug forms • Counts recombinant insulin production steps • Discusses the formulation of insulin • Defines Humalog insulin • Explain glucagon production • Defines the formulation of human growth hormone • Defines recombinant production and formulation of human growth hormone • Defines the production and formulation of biotechnological human growth hormone • Explains the formulation and production of gonadotropins • Follicle-stimulating hormone, luteinizing hormone and human chorionic • Discusses the production and formulation of gonadotropin. • Explains veterinary use of gonadotropins • Defines the biotechnological production of gonadotropins • Identifies currently approved hormones
Will be able to Evaluate Evaluate Recombinant Blood Products and Therapeutic Enzymes.
•Classifies recombinant blood coagulation factors approved for the management of coagulation disorders • Explains the production of Factor VIII • Explain the production of Factor IX, IIVa and XIII • Counts anticoagulant proteins and defines their production techniques •Lists thrombolytic agents and production methods approved for general medical use • Explain the production of albumin. •List the therapeutic enzymes • Describes the uses and production technologies of therapeutic enzymes • Describes recombinant production of DNase enzyme •Discusses the importance of antibodies in the immune system
Will be able to Evaluate Antibodies, Vaccines and Adjuvants.
• Describes immune definitions (antigen, antibody, epitope etc.) • Classifies the preparations used for immunization Discusses the humoral response • Explains cellular response Lists the production of antibodies in the body • Counts antibody types • Recognizes polyclonal antibodies • Explains the production of polyclonal antibodies • Counts the usage areas of polyclonal antibodies Identifies monoclonal antibodies • Counts the usage areas of monoclonal antibodies • names monoclonal antibodies List monoclonal antibody production methods • Recognizes hybridoma technology Describes the terms monospecific bivalan, bispecific monovalan • Explains Trioma technology • Explains Quadroma technology • Explains chemical technology • Describes chimeric antibodies with examples • Explain humanized antibodies with examples • Explain the limiting factors in hybridoma technology. • Explain the phage display technology. • Explains the production techniques of monoclonal antibodies from plants • Explain monoclonal antibody production techniques from transgenic animals. • exemplifies the antibodies used in treatment • Defines immunotherapy • Explains additional therapeutic applications of monoclonal antibodies. • Explain antibody fragments and their usage areas • Describes the historical development of AIKs • Describes the target antigen selection to develop AIK • Describes the selection of antibodies to develop AIK • Defines connector selection for AIK • Sorts openable ties • Defines hydrazone binders, Disulfide binders Peptide binders and β-glucuronide binders • Identifies inseparable binders • Explains the production techniques of AIKs • Discusses the development of formulations of AIKs • Illustrates the characterization of formulations of AIKs • Compares the stability of formulations of AIKs • Counts traditional vaccine preparations • Classifies vaccines Identifies weakened, dead or inactive bacterial vaccines • Describes the production techniques of weakened, dead or inactive bacterial vaccines. Identifies attenuated and inactive viral vaccines • Explains the production techniques of attenuated and inactive viral vaccines. • Identifies toxoid and antigen-based vaccines • Explains the production techniques of toxoid and antigen-based vaccines. • Explains modern vaccination techniques • Describes recombinant bacterial vaccines • Describes recombinant virus vaccines • Identifies anti-idotype antibody vaccines • Explains the production of synthetic peptide-based vaccines. • Describes anti-idiotype antibody vaccines • Identifies nucleic acid vaccines • Describes the preparation of nucleic acid vaccines. • Describes exogenic and endogenic pathways of nucleic acid vaccines in vivo. • Counts the application pathways of nucleic acid vaccines • Identifies artificial peptides • Recognizes cancer vaccines • Discuss development of vaccine formulation • Counts vaccine adjuvants • Counts biological substances used as adjuvants • Counts chemicals used as adjuvants • Counts particulate carrier systems used as adjuvants
Will be able to Evaluate Nucleic acid and cell-based therapeutics, Adult stem cells.
• Defines gene therapy • Interprets the general approach to gene therapy • Defines ex-vivo gene therapy • Explains in-vivo gene therapy • Recognizes the vectors used in gene therapy • Recognizes retroviral vectors Counts adenoviral and adeno related vectors • Explains the production of viral vectors • Defines non-viral vectors Counts non-viral vectors • Describes the production methods of non-viral vectors • Relates gene therapy and genetic diseases • Illustrates the use of gene therapy in cancer • Illustrates the use of gene therapy in AIDS • Defines the production of gene-based vaccines • Makes gene therapy and ethical association • Defines antisense technology • Classifies antisense oligonucleotides • Defines RNA interference (RNAi) • Defines miRNA • Defines siRNA (small interfering RNA) and illustrates its usage areas • Explains the intracellular working mechanisms of antisense oligonucleotides • Interprets the synthesis of antisense oligonucleotides according to the target gene • Interpret pharmacokinetics of antisense oligonucleotides • Illustrates the loading methods of antisense oligonucleotides to carrier systems. • Interprets the transfer of antisense oligonucleotides to the cell by carrier systems. • Interprets the stability of antisense oligonucleotides with carrier systems • Explains the advantages and disadvantages of treatment with antisense technology. • Defines the aptamer Lists the usage areas of aptamers • Explains the degradation of aptamers • Explains the therapeutic applications of aptamers • Describes the interaction of aptamers with intracellular targets • Interpret pharmacokinetics of antisense oligonucleotides • Illustrates the loading methods of aptamers to carrier systems • Interprets the transfer of aptamers to cell by carrier systems • Interprets the stability of aptamers with carrier systems • Explains the advantages and disadvantages of treatment with aptamers • Defines somatic cell • Identifies stem cell • Defines totipotent Defines the pluripotent • Recognizes embryonic stem cells • Recognizes adult stem cells • Recognizes excitable pluripotent stem cells Relates stem cells and hematopoiesis • Explain stem cell differentiation • Stem cell (stem cell) defines the treatment • Recognizes stem cell applications • Explain legal and ethical regulations regarding stem cell therapy. • Defines quality assurance in stem cell treatments • Evaluates quality assurance in stem cell research • Illustrates Advanced Therapy Medical Products (ITU) • Defines individual drug treatment
Will be able to Evaluate Biosimilars.
• Defines Biosimilars according to FDA, EMA and TITCK • Defines the reference medicinal product Classes biosimilars according to their degree after comparative analytical characterization • Explains Comparability in Biosimilar Products Lists the production process changes of the biosimilar product • Interprets the quality comparability in biosimilars • Interpret non-clinical comparability in biosimilars • Interprets clinical comparability in biosimilars • Summarizes the production of biosimilar products • Discuss the formulation of biosimilars • Discusses the determination of biosimilars Lists analytical characterization studies on biosimilar and reference products • Compares the physicochemical properties of the biosimilar product • Compares the biological activity characteristics of the biosimilar product • Compares the immunochemical properties of the biosimilar product • Summarizes the research methods of purity, impurity and contaminants of the biosimilar product • Recognizes the methods of quantification of the biosimilar product Lists the methods for determining the active substance properties List the methods of determining the finished product properties • Explains the determination of release and shelf-life limits. • Describes pharmacodynamic studies in vitro and in vivo
Will be able to Prepare Granulated Type Pharmaceutical Formulation.
• Defines granules. • Defines effervescent granules. • Lists the feature that the granule should have. • Lists the steps to prepare the granulated formulation. Lists the steps of preparing effervescent granulated formulation. • Explains preparing granules with wheat starch. • Indicates the substance and its intended use in the composition of wheat starch granules. • Makes the necessary calculations for the preparation of granules with wheat starch. • Wheat starch granule specifies the usage and purpose of use. • It prepares wheat granules with normal granules and delivers them in appropriate packaging. • Describes the preparation of effervescent granules containing sodium bicarbonate-tartaric acid. • Indicates the substance and its purpose in the composition of effervescent granule containing sodium bicarbonate-tartaric acid. • Makes the necessary calculations for the preparation of effervescent granules containing sodium bicarbonate-tartaric acid. • Indicates the usage and purpose of effervescent granule containing sodium bicarbonate-tartaric acid. • Prepares and delivers effervescent granules containing sodium bicarbonate-tartaric acid and delivered in appropriate packaging. • Describes the preparation of effervescent granules containing sodium bicarbonate-sodium dihydrogen phosphate. • Indicates the substance and its purpose in the effervescent granule composition containing sodium bicarbonate-sodium dihydrogen phosphate. • Makes the necessary calculations for the preparation of effervescent granules containing sodium bicarbonate-sodium dihydrogen phosphate. • Indicates the usage and purpose of effervescent granule containing sodium bicarbonate-sodium dihydrogen phosphate. • Prepares and delivers the effervescent granule containing sodium bicarbonate-sodium dihydrogen phosphate in a suitable package. • Explains preparation of magnesium citrate effervescent granule. • Indicates the substance and its purpose in the effervescent granule composition containing magnesium citrate. • Makes the necessary calculations for the preparation of effervescent granules containing magnesium citrate. • Indicates the usage and purpose of effervescent granule containing magnesium citrate. • Prepares and delivers effervescent granules containing magnesium citrate in appropriate packaging. • Classifies the control done in the granule. • Analyzes particle size and distribution. • Defines the concepts of diameter size, number and% stacked quantity remaining on the sieve. • Defines and makes analysis of stack angle determination. • Interprets the fluency according to the stack angle. • Interprets fluency according to flow time. • Defines and performs cluster density determination. • Defines and determines the beat density determination. • Defines the moisture quantity determination. • Defines the determination of carbon dioxide.
Will be able to Prepare Tablet Formulation.
• Defines tablet. • Classifies tablet types. • Lists the general feature of the tablets. • Lists steps to prepare tablet formulation. • Lists the excipient in the tablet composition • Defines binding (adhesive) substance and gives examples. • Classifies the lubricant. • Defines and samples the lubricant substance. • Defines Glidan substance and samples. • Defines and samples anti-adheren substance. • Introduces the single punch tablet machine and explains its usage. • Uses single punch tablet machine. • Lists tablet preparation method. • Describes the method of preparing tablets with direct pressure. • Classifies and samples the auxiliary substance used in the method of preparing tablets with direct pressure. • Describes the method of preparing tablets with pressure after granulation. • Introduces the method of preparing tablets with pressure after dry granulation. • Introduces the method of preparing tablets with pressure after wet granulation. • Describes the preparation of aspirin tablets by dry granulation method. • It indicates the substance in the aspirin tablet composition prepared by dry granulation method and its purpose of use. • It makes the necessary calculations for the preparation of aspirin tablets with the dry granulation method. • Aspirin prepared by dry granulation method indicates the usage, purpose and label of the tablet. • Prepares aspirin tablets with dry granulation method and delivers them in appropriate packaging. • Explains the preparation of APC tablet by dry granulation method. • It specifies the substance and the purpose of use in the APC tablet composition by the dry granulation method. • It makes the necessary calculations for the preparation of APC tablets with the dry granulation method. • APC tablet prepared by dry granulation method indicates the usage, purpose and label. • Prepares APC tablets with dry granulation method and delivers them in appropriate packaging. • Describes the preparation of tablets containing vitamin C and lactose starch granules by dry granulation method. • It specifies the substances and their intended use in the composition of the tablet prepared with dry granulation method with vitamin C and lactose starch granules. • It makes the necessary calculations for the preparation of tablets containing vitamin C and lactose starch granules with the dry granulation method. • It specifies the usage form, purpose and label of the tablet prepared with dry granulation method with vitamin C and lactose starch granules. • It prepares tablets with vitamin C and lactose starch granules with dry granulation method and delivers them in appropriate packaging. • Describes the preparation of lozenge tablets by dry granulation method. • Indicates the substance and its purpose in the composition of the lozenge tablet prepared by the dry granulation method. • Makes the necessary calculations for the preparation of lozenge tablets by the dry granulation method. • It specifies the usage, purpose and label of lozenge tablet with dry granulation method. • Prepares lozenge tablets with dry granulation method and delivers them in appropriate packaging. • Explains the preparation of tablets containing sodium bicarbonate with wet granulation method. • It indicates the substance in the tablet composition containing sodium bicarbonate prepared by wet granulation method and its purpose of use. • Makes the necessary calculations for the preparation of tablets containing sodium bicarbonate with wet granulation method. • It indicates the usage form, purpose and label of the tablet containing sodium bicarbonate prepared by wet granulation method. • Prepares tablets containing sodium bicarbonate with wet granulation method and delivers them in appropriate packaging. • Explains the preparation of mixture tablets with wet granulation method. • It indicates the substance in the tablet composition and its purpose of use with the wet granulation method. • It makes the necessary calculations for the preparation of the mixture tablet with the wet granulation method. • The mixture prepared by the wet granulation method indicates the use, purpose and label of the tablet. • Prepares the blended tablet with the wet granulation method and delivers it in the appropriate packaging. • Explains preparing a research tablet containing saccharin with wet granulation method. • Indicates the substance and its intended use in the composition of the research tablet containing saccharin prepared by the wet granulation method. • Makes the necessary calculations for the research tablet containing saccharin by wet granulation method. • The research tablet containing saccharin prepared by the wet granulation method specifies the method of use, its purpose and label. • Prepares the research tablet containing saccharin with wet granulation method and delivers it in appropriate packaging. • Describes the preparation of tablets containing novalgine (metamizole sodium) by wet granulation method. • Indicates the substance in the tablet composition containing novaljin (metamizole sodium) prepared by wet granulation method and its purpose of use. • It makes the necessary calculations for the tablet containing novalgin (metamizole sodium) by wet granulation method. • It specifies the usage, purpose and label of tablet containing novalgine (metamizole sodium) prepared by wet granulation method. • Prepares tablets with novaljin (metamizole sodium) by wet granulation method and delivers them in appropriate packaging. • Explains the preparation of tablets containing betamethasone by wet granulation method. • Indicates the substances in the tablet composition containing betamethasone prepared by wet granulation method and their intended use. • Makes the necessary calculations for the tablet containing betamethasone by wet granulation method. • It specifies the usage, purpose and label of tablet containing betamethasone prepared by wet granulation method. • Prepares tablets containing betamethasone with wet granulation method and delivers them in appropriate packaging. • Describes the preparation of tablets containing sulfamethoxazole-trimethoprim by wet granulation method. • It specifies the substance and its intended use in the tablet composition containing sulfamethoxazole-trimethoprim prepared by wet granulation method. • It makes the necessary calculations for the tablet containing sulfamethoxazole-trimethoprim with wet granulation method. • It specifies the usage, purpose and label of tablet containing sulfamethoxazole-trimethoprim prepared by wet granulation method. • Prepares tablets containing sulfamethoxazole-trimethoprim with the wet granulation method and delivers them in appropriate packaging.
Will be able to Prepare Effervescent Tablet
• Defines the terms monohydrate, dihydrate and trihydrate. • Defines the equivalent calculation required for effervescent tablet. • Describes the preparation of effervescent tablets containing aspirin. • Indicates the substance and its intended use in the composition of the effervescent tablet containing aspirin. • Makes the necessary calculations for the effervescent tablet containing aspirin. • It indicates the usage, purpose and label of the effervescent tablet containing aspirin. • Prepares effervescent tablets containing aspirin and delivers them in appropriate packaging. • Describes the preparation of effervescent tablets containing vitamin C. • Indicates the substance and its intended use in the composition of the effervescent tablet containing vitamin C. • Makes the necessary calculations for effervescent tablets containing vitamin C. • It specifies the usage, purpose and label of effervescent tablet containing vitamin C. • Prepares effervescent tablets containing Vitamin C and delivers them in appropriate packaging.
Will be able to Prepare Modified Release Tablet.
• Identifies the modified release tablet. • Lists the modified release tablet. • Describes the preparation of tablets containing ketorolac tromethamine-carbopol, which provides controlled release by direct compression method. • Indicates the substance and its intended use in the composition of the tablet containing ketorolac tromethamine-carbopol, which provides controlled release by direct compression method. • It makes the necessary calculations for the preparation of tablets containing ketorolac tromethamine-carbopol, which provides controlled release by direct compression method. • Indicates the use, purpose and label of the tablet containing ketorolac tromethamine-carbopol, which provides controlled release by direct compression method. • It prepares tablets containing ketorolac tromethamine-carbopol which provides controlled release by direct printing method and delivers them in appropriate packaging. • Describes the preparation of tablets containing dimenhydrinate-HEC, which provides controlled release by wet granulation method. • Indicates the substance and its intended use in the composition of the tablet containing dimenhydrinate-HEC, which provides controlled release by wet granulation method. • It makes the necessary calculations for the preparation of tablets containing dimenhydrinate-HEC, which provides controlled release with wet granulation method. • It specifies the usage, purpose and label of the tablet containing dimenhydrinate-HEC, which provides controlled release by wet granulation method. • Prepares tablets with dimenhydrinate-HEC that provides controlled release by wet granulation method and delivers them in appropriate packaging. • Describes the preparation of tablets containing diclofenac sodium, which provides controlled release with wet granulation method. • Indicates the substance and its intended use in the composition of the tablet containing diclofenac sodium, which provides controlled release with wet granulation method. • Makes the necessary calculations for the preparation of tablets containing diclofenac sodium, which provides controlled release with wet granulation method. • It specifies the usage, label and label of the tablet containing diclofenac sodium, which provides controlled release by wet granulation method. • Prepares tablets with diclofenac sodium, which provides controlled release with wet granulation method, and delivers them in appropriate packaging.
Will be able to Prepare Bioadhesive Tablet
• Defines the bioadhesive dosage form Lists the superiority of the bioadhesive dosage form. • Lists the feature of the bioadhesive tablet. • Lists the steps of preparing bioadhesive tablets. • Classifies the vaginal bioadhesive tablet. • Classifies the buccal bioadhesive tablet. • Describes the preparation of a vaginal bioadhesive tablet containing acyclovir-HPMC. • Indicates the substance and its intended use in the composition of the vaginal bioadhesive tablet containing acyclovir-HPMC. • Makes the necessary calculations for the preparation of a vaginal bioadhesive tablet containing acyclovir-HPMC. • It specifies the usage, purpose and label of vaginal bioadhesive tablet containing acyclovir-HPMC. • Prepares and delivers vaginal bioadhesive tablets containing acyclovir-HPMC in appropriate packaging. • Describes the preparation of a vaginal bioadhesive tablet containing Acyclovir-Carbopol® 934. • It specifies the substances and their intended use in the composition of vaginal bioadhesive tablets containing Acyclovir- Carbopol® 934. • Acyclovir-Carbopol® 934 contains vaginal bioadhesive tablet preparation for the preparation. • Indicates the use, purpose and label of vaginal bioadhesive tablet containing Acyclovir- Carbopol® 934. • Prepares and delivers vaginal bioadhesive tablets containing Acyclovir- Carbopol 934 in appropriate packaging. • Describes the preparation of a vaginal bioadhesive tablet containing acyclovir-MC. • It indicates the substance and its intended use in the composition of vaginal bioadhesive tablets containing acyclovir-MC. • Makes the necessary calculations for the preparation of a vaginal bioadhesive tablet containing acyclovir-MC. • It specifies the usage, purpose and label of vaginal bioadhesive tablet containing acyclovir-MC. • Prepares and delivers vaginal bioadhesive tablets containing acyclovir-MC in appropriate packaging. • Describes the preparation of buccal bioadhesive tablets containing micanazol-HPMC. • Indicates the substance and its intended use in the composition of buccal bioadhesive tablets containing Micanazol-HPMC. • Make the necessary calculations for the preparation of buccal bioadhesive tablets containing Micanazol-HPMC. • Mucanazole - Indicates the use, purpose and label of the buccal bioadhesive tablet containing HPMC. • Prepares mykaanazole-buccal bioadhesive tablet containing HPMC and delivers it in suitable packaging. • Describes the preparation of a buccal bioadhesive tablet containing myxanazole-carbomer. • Indicates the substance and its intended use in the composition of buccal bioadhesive tablets containing myxanazole-carbomer. • Makes the necessary calculations for the preparation of buccal bioadhesive tablets containing myxanazole-carbomer. • Mucanazole - buccal bioadhesive tablet containing carbomer indicates the use, purpose and label. • Prepares a buccal bioadhesive tablet containing mycanaazole-carbomer and delivers it in an appropriate package. • Describes the preparation of buccal bioadhesive tablets containing micanazol- HPMC- carbomer. • Indicates the substance and its intended use in the composition of buccal bioadhesive tablets containing micanazol- HPMC- carbomer. • Makes the necessary calculations for the preparation of buccal bioadhesive tablets containing myxanazole-HPMC-carbomer. • Indicates the use, purpose and label of buccal bioadhesive tablet containing mycoanazole-HPMC-carbomer. • Prepares a buccal bioadhesive tablet containing myxanazole-HPMC-carbomer and delivers it in an appropriate package.
Will be able to Perform Tablet Control.
• Explains the importance of tablet control. • Lists the finished product control done on the tablet. • Defines the resistance to breakage. • Defines mass uniformity. • Defines content uniformity. • Defines dissolution rate determination. • Determines the resistance against breakage. • Describes the determination of mass uniformity on the tablet. • Describes the determination of the content uniformity of the tablet. • Determines the dissolution rate in the tablet. • Determines the amount on the tablet with the spectrophotometric method. • Creates linear equation for the spectrophotometric method. • Calculates the correlation coefficient for the spectrophotometric method. • Draws a calibration curve for the spectrophotometric method.
Will be able to Prepare Coated Tablet.
• Identifies the coated tablet. • Lists the substance used in tablet coating. • Defines sugar coating. • Defines the film coating. • Describes the coating distributed in the intestine. Lists tablet coating technique. • Explains coating in the boiler. • Explains coating with fluidized bed system. • Lists the control performed on the coated tablet. • Identifies the controls on the coated tablet.
Will be able to Prepare Microcapsule.
• Identifies the microcapsule. • Lists the intended use of the microcapsule. • Lists the microcapsule preparation method. • Lists the control made in the microcapsule. • Describes the control in the microcapsule.
Will be able to Perform Water, Packaging Materials and Surgical Materials Controls.
• Controls ion in distilled water. • Controls heavy metal in distilled water. • Controls the substance that can be oxidized in distilled water. • It controls the bulb glass. • The drug controls the bottle. • Determines the sinking time of the cotton. • It controls ion in cotton. • It controls the reducer material in cotton. • It controls the number of weft-warp in the gauze. • It performs ion control in gauze. • It controls the reducer material in the gauze.
Will be able to Evaluate Biotechnology Laboratory Techniques.
• Counts the devices used • Explains the intended use •Classifies the devices used for protein and genetic material (DNA / RMNA) analysis • Classifies the devices used in the preparation of formulations containing protein and genetic material (DNA / RMNA). • Identifies devices that sterilize materials used in formulation preparation. • Explains the working principles of the devices that sterilize the materials used in the preparation of the formulation. • Diagnoses the clean room • Counts the devices in the clean room • Counts sterile cabin types • Explains the working principle of the sterile cabinet.
Will be able to Apply Electrophoresis Methods.
• Classifies electrophoresis types • Explains the purpose of horizontal gel electrophoresis method •Lists the preparation steps of horizontal gel electrophoresis method • Counts the basic parts of horizontal gel electrophoresis device • Counts horizontal gel electrophoresis buffer solutions • Prepares horizontal gel electrophoresis buffer solutions • Sterilizes horizontal gel electrophoresis buffer solutions •Lists the points to be considered in the preparation of the gel to be used for horizontal gel electrophoresis process. • Prepares horizontal gel electrophoresis gel • Makes the process of pouring the prepared gel into the gel tank of the horizontal gel electrophoresis device. •Lists the issues to be considered in the preparation of the genetic material to be loaded on the gel. • Makes the loading of genetic material on the gel • Determines the adjustment of the voltage and time required for electrophoresis • Describes the vertical gel electrophoresis method • Explains the purpose of vertical gel electrophoresis method Lists the preparation steps of vertical gel electrophoresis method • Counts the basic parts of the vertical gel electrophoresis device • Vertical gel counts electrophoresis buffer solutions • Prepares vertical gel electrophoresis buffer solutions • Sterilizes vertical gel electrophoresis buffer solutions • Lists the points to be considered in the preparation of the gel to be used for vertical gel electrophoresis process. • Prepares vertical gel electrophoresis gel • Makes the process of pouring the prepared gel into the gel tank of the vertical gel electrophoresis device. •Lists the points to be considered in the preparation of the protein material to be loaded on the gel. •Denatures the protein material to be loaded on the gel • Loading denatured protein material into the gel • Determines the adjustment of the voltage and time required for electrophoresis •Lists the points to be considered in removing the gel at the end of electrophoresis • Chooses the appropriate dyes to be used in the imaging of the removed gel. • Performs staining process to display the protein in the gel •Identifies the gel imaging device • Counts the essential parts of the gel imaging device • Explains the working principles of gel imaging device •Lists the issues in placing the gel on the device • Makes the gel to be placed on the imaging device appropriately. • It transfers the gel image to the computer with the imaging system. • Evaluates analysis results on the image
Will be able to Prepare Formulation with Biotechnological Product.
Counts gene carrier vectors • Describes the preparation techniques of non-viral gene delivery systems. • Counts the loading methods of Genetic Material (DNA / RNA) to the carrier system • Makes the loading of Genetic Material (DNA / RNA) into the carrier system • Determines the rate of attachment of the carrier system to genetic material • Counts the methods of quantification of genetic material loaded on the carrier system • Makes particle size analysis of genetic material loaded carrier system • Makes zeta potential analysis of genetic material loaded carrier system • Analyzes the genetic material loaded carrier system pH • Describes the extraction methods of the genetic material from the carrier system. List the methods to determine the stability of the extracted genetic material • Quantifies the extracted genetic material • Investigates the stability of genetic material loaded on the carrier system in serum • Investigates the stability of genetic material loaded on the carrier system to nuclease (DNase / RNase) • Explains how biological product loaded carrier system is transferred to cells (transfection) • Explains how transfection is displayed • Explains the analysis that can be done on cells after transfection. • Explains how analysis results are evaluated.