Akademik Dersler - Tanıtım

Course Title	Code	Compulsory/Elective	Laboratory + Practice	ECTS
Oral Drug Absorption and Evaluation Techniques	FTE635	I. SEMESTER	3+0	7.5

Language of Instruction	Türkçe
Course Type	Elective Courses
Course Instructor(s)	PROF. DR. MUSTAFA SİNAN KAYNAK
Mode of Delivery	The mode of delivery of this course is face to face.
Prerequisites	There is no prerequisite or co-requisite for this course.
Courses Recomended	There is no recommended optional programme component for this course.
Recommended Reading List	Dahlgren D, Lennernäs H. Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches. Pharmaceutics. 2019;11(8):411. Published 2019 Aug 13. doi:10.3390/pharmaceutics11080411• Cagno MP, Clarelli F, Våbenø J, Lesley C, Rahman SD, Cauzzo J, Franceschinis E, Realdon N, Stein PC. Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements. Molecular Pharmaceutics 2018 15 (4), 1488-1494. DOI:10.1021/acs.molpharmaceut.7b01053
Assessment methods and criteria	Mid-term exam (40%), Final exam (60%) (Homework, Presentation or Written exams)
Work Placement	Practical training is not required for this programme.
Catalog Content	Introduction, Definitions; Anatomy and Physiology of the GI Tract; Status of Absorption Determination in the Regulations of Health Authorities; In Vitro Methods – I (PAMPA, Other techniques); Cell Cultures – I (Caco-2); Cell Cultures – II (MDCK, Other cells); Ex-Vivo Methods (Ussing-Chamber, Everted gut sac technique); In Situ Methods – I (Delusio technique, Closed loop technique); In Situ Methods – II (Single pass intestinal perfusion technique); In Vivo Methods – I (Tube techniques); In Vivo Methods – II (Mass balance studies); In Vivo Methods – III (Bioavailability studies); Examples and Applications – I; Examples and Applications – II.